Pls check if the mailbox that you are trying to send the mail from is not marked as Postmaster? You can do that in Email and Conferences >> Settings >> Mail and Conference Settings >> Postmaster field
More explanation @Paul:
When the issue occurs, should see if restarting presence or lookup helps. If so - that is the issue and should be sorted. First need to ensure that that is the issue...
Hello!
You can mark it as closed as option. If document is connected with other documents you can not delete it so you will not be able to delete PO, as you will not be able to remove Goods receipt...